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Evolución clonal en la leucemia mieloide aguda recidivante revelada por la secuenciación del genoma completo

Li Ding1, Timothy J Ley, David E Larson

  • 1The Genome Institute, Washington University, St Louis, Missouri 63108, USA.

Nature
|January 13, 2012
PubMed
Resumen

La recaída de la leucemia mieloide aguda (LMA) implica nuevas mutaciones y evolución clonal. La quimioterapia puede impulsar estos cambios, ya que el clon fundador a menudo persiste y adquiere mutaciones adicionales.

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