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Gastrulation01:56

Gastrulation

62.9K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
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Pedigree Analysis01:35

Pedigree Analysis

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Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Lineage Commitment01:21

Lineage Commitment

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Commitment is the  process whereby stem cells:
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Karyotyping01:17

Karyotyping

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Gene Duplication and Divergence02:37

Gene Duplication and Divergence

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The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
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Video Experimental Relacionado

Updated: Nov 6, 2025

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain
09:44

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain

Published on: May 20, 2022

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El rastreo del linaje traza el linaje.

Kai Kretzschmar1, Fiona M Watt

  • 1Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

Cell
|January 24, 2012
PubMed
Resumen
Este resumen es generado por máquina.

El rastreo de linaje identifica toda la progenie celular, crucial para comprender el desarrollo de los tejidos y las enfermedades. Las técnicas avanzadas ofrecen nuevas formas de estudiar la biología de las células madre y las vías de señalización.

Área de la Ciencia:

  • Biología del desarrollo Biología del desarrollo.
  • Biología de las células madre Biología de las células madre

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  • Investigación de tejido de mamíferos.
  • Sus antecedentes:

    • El rastreo del linaje, originado en los estudios de invertebrados del siglo XIX, es ahora vital para la investigación de tejidos de mamíferos adultos.
    • Ayuda a comprender el desarrollo de los tejidos, la homeostasis y los procesos de la enfermedad.
    • La combinación del rastreo del linaje con la manipulación experimental de señales de destino celular mejora su utilidad.