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Las células T CD8 tolerantes rescatadas son preprogramadas para restablecer el estado tolerante

Andrea Schietinger1, Jeffrey J Delrow, Ryan S Basom

  • 1Department of Immunology, University of Washington (UW), Seattle, WA 98195, USA.

Science (New York, N.Y.)
|January 24, 2012
PubMed
Resumen

Las células T CD8 tolerantes pueden activarse temporalmente en condiciones linfopénicas, pero la auto-tolerancia se vuelve a imponer al recuperarse. Esto sugiere que la regulación epigenética mantiene la tolerancia, ofreciendo nuevas estrategias terapéuticas para la autoinmunidad y el cáncer.

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