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Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
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Published on: September 17, 2017

La revelación de estructuras de proteínas en la síntesis de péptidos en fase sólida por RMN de estado sólido 13C:

Songlin Wang1, Yoshitaka Ishii

  • 1Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607, USA.

Journal of the American Chemical Society
|January 28, 2012
PubMed
Resumen

La síntesis de péptidos en fase sólida (SPPS) lucha con secuencias largas debido a la agregación. Un nuevo método de RMN de estado sólido revela que los péptidos beta-amiloide se desdoblan erróneamente en hebras beta durante el SPPS, lo que explica los fallos de síntesis.

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