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Imaging Dpp Release from a Drosophila Wing Disc
Published on: October 30, 2019
Comentario sobre "Dynamics of dpp signaling and proliferation control" (Dinámica de la señalización y el control de
Gerald Schwank1, Schu-Fee Yang, Simon Restrepo
1Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Science (New York, N.Y.)
|January 28, 2012
Resumen
Las tasas de crecimiento en los discos de las alas de Drosophila no dependen del aumento de los niveles de señalización Decapentaplegia (Dpp). Nuestros hallazgos contradicen modelos anteriores que sugieren que el aumento de la señalización Dpp dicta la longitud del ciclo celular.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Genética La genética.
- Biología celular Biología celular.
Sus antecedentes:
- Investigaciones anteriores sugirieron una correlación entre las tasas de crecimiento de los discos de las alas de Drosophila y el aumento de los niveles de señalización decapentaplegia (Dpp).
- El modelo prevaleciente propuso que la tasa de aumento de Dpp determina la duración del ciclo celular en estos tejidos en desarrollo.
Objetivo del estudio:
- Investigar el papel del aumento de los niveles de señalización Dpp en la regulación de la longitud del ciclo celular.
- Desafiar el modelo existente al examinar las tasas de crecimiento cuando el aumento de la señalización Dpp está genéticamente bloqueado.
Principales métodos:
- Manipulación genética para anular el aumento de los niveles de señalización de Dpp en los discos de las alas de Drosophila.
- Análisis comparativo de la duración del ciclo celular y las tasas de crecimiento entre las células genéticamente modificadas y las de tipo silvestre.
Principales resultados:
- Las células con una señalización Dpp genéticamente abrogada aumentan las tasas de crecimiento comparables a las células de tipo silvestre.
- Se descubrió que la tasa de aumento de Dpp no era el factor determinante de la longitud del ciclo celular.
Conclusiones:
- Los hallazgos contradicen la hipótesis de que la tasa de aumento de Dpp dicta la longitud del ciclo celular.
- El crecimiento celular en los discos de las alas de Drosophila está regulado por mecanismos independientes de la tasa de aumento de la señalización Dpp.
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