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Un mutante de la pirrolisil-tRNA sintetasa diseñado racionalmente con un amplio espectro de sustrato

Yane-Shih Wang1, Xinqiang Fang, Ashley L Wallace

  • 1Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA.

Journal of the American Chemical Society
|February 1, 2012
PubMed
Resumen

Los investigadores incorporaron genéticamente nuevos derivados de fenilalanina en proteínas utilizando una enzima diseñada y tRNA. Esto amplía el conjunto de herramientas para crear proteínas con nuevos aminoácidos en E. coli.

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