Jove
Visualize
Contáctanos

Videos de Conceptos Relacionados

Genetic Lingo01:11

Genetic Lingo

Overview
Ascites01:19

Ascites

DefinitionAscites is the buildup of fluid inside the peritoneal cavity. It occurs when fluid moves out of the vascular system faster than the peritoneal lymphatics can remove it. This fluid shift is most commonly seen in liver cirrhosis but can also appear in several other systemic disorders.EtiologyCirrhosis remains the leading cause of ascites. Other conditions that can contribute include:Heart failureConstrictive pericarditisAbdominal cancersNephrotic syndromeSevere protein–calorie...
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Cytotoxic Edema: Pathophysiology01:21

Cytotoxic Edema: Pathophysiology

Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Arerugi = [Allergy]·2026
Same author

Classification of angioedema types using decision tree modeling.

Frontiers in immunology·2026
Same author

Reference intervals for functional lymphocyte proliferation studies using <sup>3</sup>H thymidine uptake in adults.

Journal of immunological methods·2025
Same author

Factors contributing to non-compliance with on-demand treatment guidelines in hereditary angioedema.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·2025
Same author

Hereditary Angioedema with Normal C1 Inhibitor: an Updated International Consensus Paper on Diagnosis, Pathophysiology, and Treatment.

Clinical reviews in allergy & immunology·2025
Same author

Clinical profile and management of pediatric hereditary angioedema in resource-constrained settings: our experience from a single centre in North India.

Immunologic research·2024
Same journal

Assisted dying and the silencing of medicine's next generation.

Lancet (London, England)·2026
Same journal

Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

Lancet (London, England)·2026
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026
Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026
Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026
Ver todos los artículos relacionados
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Video Experimental Relacionado

Updated: May 25, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

El angioedema hereditario es un angioedema hereditario.

Hilary Longhurst1, Marco Cicardi

  • 1Department of Immunology, Barts and The London National Health Service Trust, Whitechapel, London, UK. hilary.longhurst@bartsandthelondon.nhs.uk

Lancet (London, England)
|February 7, 2012
PubMed
Resumen
Este resumen es generado por máquina.

El angioedema hereditario (HAE) es el resultado de la deficiencia del inhibidor C1, que causa hinchazón debido a la bradicinina incontrolada. Esta revisión cubre el HAE.

Más Videos Relacionados

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
07:21

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Published on: September 28, 2015

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
06:38

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Videos de Experimentos Relacionados

Last Updated: May 25, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
07:21

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Published on: September 28, 2015

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
06:38

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Área de la Ciencia:

  • Inmunología Inmunología.
  • Genética La genética.
  • Fisiopatología Fisiopatología.

Sus antecedentes:

  • El angioedema hereditario (HAE) es un trastorno genético raro caracterizado por episodios recurrentes de hinchazón.
  • Se deriva de una deficiencia heterocigótica del inhibidor C1 (C1-INH), un regulador clave de las vías inflamatorias.
  • El deterioro de la función C1-INH conduce a la sobreproducción de bradicinina, un potente mediador de la inflamación y la vasodilatación.

Objetivo del estudio:

  • Proporcionar una revisión exhaustiva de las manifestaciones clínicas, los enfoques de diagnóstico y las estrategias de manejo para HAE.
  • Para resaltar los avances recientes en las opciones terapéuticas para los ataques agudos de HAE.
  • Para enfatizar la naturaleza potencialmente peligrosa para la vida de la participación laríngea en pacientes con HAE.

Principales métodos:

  • Revisión de la literatura sobre las características clínicas, el diagnóstico y el tratamiento del angioedema hereditario.
  • Centrarse en los tratamientos actuales y emergentes para los episodios de hinchazón aguda.
  • Análisis de los datos de los pacientes con respecto a las características de la hinchazón y los resultados.

Principales resultados:

  • La HAE se presenta con inflamaciones cutáneas o mucosas intermitentes, que a menudo afectan la cara, las extremidades y el tracto gastrointestinal.
  • Los episodios de hinchazón pueden causar desfiguración, dolor y una obstrucción laríngea potencialmente fatal.
  • A pesar de la profilaxis, aproximadamente el 50% de los pacientes experimentan inflamaciones laríngeas potencialmente fatales.

Conclusiones:

  • El diagnóstico preciso y la gestión oportuna son cruciales para mejorar la calidad de vida y prevenir resultados fatales en pacientes con AEH.
  • Los tratamientos más nuevos ofrecen una mayor eficacia en el manejo de los ataques agudos de HAE.
  • Se necesita investigación continua para refinar aún más el manejo de la AEH y explorar nuevos objetivos terapéuticos.