Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

15.2K
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
15.2K
Regulated Protein Degradation02:58

Regulated Protein Degradation

8.9K
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
8.9K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

9.6K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
9.6K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

8.7K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
8.7K
Activation Energy01:26

Activation Energy

86.7K
Activation energy is the minimum amount of energy necessary for a chemical reaction to move forward. The higher the activation energy, the slower the rate of the reaction. However, adding heat to the reaction will increase the rate, since it causes molecules to move faster and increase the likelihood that molecules will collide. The collision and breaking of bonds represents the uphill phase of a reaction and generates the transition state. The transition state is an unstable high-energy state...
86.7K
Activation and Inactivation of G Proteins01:22

Activation and Inactivation of G Proteins

11.5K
Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high...
11.5K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Social Determinants of Health and Impact on Cochlear Implant Performance.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2026
Same author

Validation of an Adaptive Sinonasal Outcome Test.

JAMA otolaryngology-- head & neck surgery·2026
Same author

Concordance Between an Adaptive Sino-Nasal Outcome Test and Imaging Results in Chronic Rhinosinusitis.

JAMA otolaryngology-- head & neck surgery·2026
Same author

Hearing Aid Efficacy-Timely Trial Finds Professional Guidance Trumps Costly Tech.

JAMA otolaryngology-- head & neck surgery·2026
Same author

JAMA Otolaryngology-Head & Neck Surgery-The Year in Review, 2025.

JAMA otolaryngology-- head & neck surgery·2026
Same author

Opioid Dependency After Craniomaxillofacial Trauma Surgery.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026

Video Experimental Relacionado

Updated: Feb 6, 2026

Protein Modifications: Protein Kinases and Phosphatases
02:54

Protein Modifications: Protein Kinases and Phosphatases

15.2K

Amoxicilina para la rinosinusitis aguda: un ensayo controlado aleatorizado.

Jane M Garbutt1, Christina Banister, Edward Spitznagel

  • 1Division of General Medical Sciences, Washington University School of Medicine, Campus Box 8005, 660 S Euclid Ave, St Louis, MO 63110, USA. jgarbutt@dom.wustl.edu

JAMA
|February 17, 2012
PubMed
Resumen

La amoxicilina no mejoró significativamente los síntomas de rinosinusitis aguda al día 3 en comparación con el placebo. Si bien se observó una cierta mejora de los síntomas al día 7, los resultados generales fueron similares, lo que cuestiona el uso rutinario de antibióticos.

Más Videos Relacionados

Regulated and Targeted Protein Degradation
02:58

Regulated and Targeted Protein Degradation

8.9K
Covalently Linked Protein Regulators and Post-translational Modification
02:04

Covalently Linked Protein Regulators and Post-translational Modification

9.6K

Videos de Experimentos Relacionados

Last Updated: Feb 6, 2026

Protein Modifications: Protein Kinases and Phosphatases
02:54

Protein Modifications: Protein Kinases and Phosphatases

15.2K
Regulated and Targeted Protein Degradation
02:58

Regulated and Targeted Protein Degradation

8.9K
Covalently Linked Protein Regulators and Post-translational Modification
02:04

Covalently Linked Protein Regulators and Post-translational Modification

9.6K

Área de la Ciencia:

  • La medicina clínica es la medicina clínica.
  • Enfermedades infecciosas Enfermedades infecciosas.
  • Farmacología Farmacología.

Sus antecedentes:

  • El uso de antibióticos para la rinosinusitis aguda (ARS) es común a pesar de la limitada evidencia que respalda su eficacia.
  • Comprender el beneficio incremental de los antibióticos sobre el tratamiento sintomático es crucial para las directrices clínicas.

Objetivo del estudio:

  • Evaluar el beneficio añadido de la amoxicilina frente al placebo en adultos diagnosticados con rinosinusitis aguda.
  • Evaluar el impacto de la amoxicilina en la calidad de vida y la resolución de los síntomas en pacientes con ERA.

Principales métodos:

  • Un ensayo aleatorizado, controlado con placebo, en el que participaron 166 adultos con rinosinusitis aguda diagnosticada clínicamente.
  • Los participantes recibieron un curso de 10 días de amoxicilina o placebo, junto con tratamientos sintomáticos según sea necesario.
  • Los resultados, incluida la calidad de vida (Sinonasal Outcome Test-16) y la mejora de los síntomas, se evaluaron en múltiples puntos de tiempo.

Principales resultados:

  • No hay diferencia significativa en las puntuaciones de la prueba de resultado sinonasal-16 entre los grupos de amoxicilina y placebo en el día 3 o el día 10.
  • Se observó una mejora estadísticamente significativa en la notificación de síntomas que favorecía a la amoxicilina al día 7 (P = .02).
  • No se encontraron diferencias significativas en otros resultados secundarios, incluida la recurrencia, recaída o eventos adversos.

Conclusiones:

  • Un ciclo de 10 días de amoxicilina no demostró un beneficio significativo sobre el placebo en la reducción de los síntomas de rinosinusitis aguda al día 3.
  • Los hallazgos sugieren que la prescripción rutinaria de antibióticos para la rinosinusitis aguda puede no estar justificada, enfatizando la necesidad de un uso juicioso de antibióticos.