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Una proteína de unión a esteroles integra el metabolismo lipídico endosómico con la señalización TOR y la detección

Carl J Mousley1, Peihua Yuan, Naseem A Gaur

  • 1Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7090, USA. mousley@email.unc.edu

Cell
|February 21, 2012
PubMed
Resumen

La proteína Kes1 regula la detección de nutrientes celulares al inhibir la señalización del fosfatidilinositol-4-fosfato, lo que afecta la activación de TORC1 y la expresión génica a través de Gcn4. Esto vincula el metabolismo lipídico con las vías de respuesta de los nutrientes.

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