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La tolerancia a las enfermedades como estrategia de defensa.
Ruslan Medzhitov1, David S Schneider, Miguel P Soares
1Howard Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA. ruslan.medzhitov@yale.edu
Science (New York, N.Y.)
|February 25, 2012
Resumen
La tolerancia a las enfermedades, una estrategia de defensa del huésped, reduce el impacto de la infección en la aptitud. Comprender este mecanismo pasado por alto ofrece nuevos enfoques de tratamiento para enfermedades infecciosas y otras.
Área de la Ciencia:
- Inmunología Inmunología.
- Interacciones huésped-patógeno.
- Enfermedades infecciosas Enfermedades infecciosas.
Sus antecedentes:
- El sistema inmunológico elimina principalmente los patógenos.
- Los organismos huéspedes también pueden mitigar los efectos negativos de la infección en la condición física.
- La tolerancia a las enfermedades es una estrategia de defensa del huésped poco estudiada.
Objetivo del estudio:
- Introducir la "tolerancia a la enfermedad" como un concepto clave en inmunología.
- Ampliar la comprensión de las interacciones huésped-patógeno.
- Explorar nuevas vías terapéuticas para las enfermedades.
Principales métodos:
- Análisis conceptual de la tolerancia a la enfermedad.
- Revisión de la literatura existente sobre los mecanismos de defensa del huésped.
- Identificación de aspectos pasados por alto de las interacciones huésped-patógeno.
Principales resultados:
- La tolerancia a las enfermedades representa una estrategia de defensa del huésped distinta y subestimada.
- La integración de la tolerancia a la enfermedad amplía el alcance del estudio inmunológico.
- Los mecanismos de tolerancia a las enfermedades son cruciales para la supervivencia y el bienestar del huésped.
Conclusiones:
- La tolerancia a las enfermedades es un componente crítico, pero pasado por alto, de la defensa del huésped.
- Es esencial una mayor investigación sobre los mecanismos de tolerancia a las enfermedades.
- Este concepto ofrece nuevos objetivos terapéuticos para enfermedades infecciosas y otras.
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