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La base celular de la inhibición interhemisférica mediada por el GABA (B)
Lucy M Palmer1, Jan M Schulz, Sean C Murphy
1Physiologisches Institut, Universität Bern, Bühlplatz 5, CH-3012 Bern, Switzerland.
Science (New York, N.Y.)
|February 25, 2012
Resumen
La inhibición interhemisférica, mediada por los receptores GABA (((B), silencia el disparo de las neuronas piramidales a través de las dendritas apicales. Esta inhibición metabotrópica es crucial para la salida cortical y depende de la actividad neuronal.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- La neurociencia celular es la neurociencia celular.
- Los sistemas sensoriales son sistemas sensoriales.
Sus antecedentes:
- La inhibición interhemisférica regula la rivalidad cortical a través de las vías callosas.
- La inhibición de larga duración está relacionada con los receptores GABA (B) pero se entiende mal a nivel celular.
Objetivo del estudio:
- Para dilucidar los mecanismos celulares de la inhibición interhemisférica de larga duración.
- Para investigar el papel de los receptores GABA (B) en la inhibición de la activación neuronal.
Principales métodos:
- Registros electrofisiológicos de las neuronas piramidales de la capa 5 de la corteza somatosensorial de la rata.
- Estimulación de las vías sensoriales contralateral e ipsilateral.
- Análisis de los mecanismos inhibidores que actúan sobre las dendritas apicales.
Principales resultados:
- El disparo de las neuronas piramidales provocado por la estimulación sensorial contralateral fue inhibido durante cientos de milisegundos por la estimulación ipsilateral.
- La inhibición se produjo directamente en las dendritas apicales a través de las interneuronas de la capa 1.
- El proceso inhibidor dependía de la activación de las células piramidal, utilizando la inhibición metabotrópica de las corrientes dendríticas activas.
Conclusiones:
- El estudio revela el microcircuito subyacente a la inhibición interhemisférica.
- Las propiedades dendríticas activas son críticas para regular la salida cortical a través de este mecanismo inhibidor.
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