Video Experimental Relacionado
Updated: Aug 2, 2026
07:45
An Explant Assay for Assessing Cellular Behavior of the Cranial Mesenchyme
Published on: January 20, 2013
Control mesodérmico de la identidad de las células neurales: inducción de la placa del suelo por el notocordo
M Placzek1, M Tessier-Lavigne, T Yamada
1Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032.
Science (New York, N.Y.)
|November 16, 1990
Resumen
La notocorda, una estructura en el desarrollo de los vertebrados, envía señales a las células de la placa del suelo. Esta señal es crucial para el desarrollo de la placa del suelo y la función en el sistema nervioso.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Biología del desarrollo Biología del desarrollo.
- Embriología Embriología.
Sus antecedentes:
- La placa del piso es un centro clave de señalización de la línea media en el tubo neural de los vertebrados.
- Regula procesos cruciales como la diferenciación celular y la orientación axonal durante el desarrollo del sistema nervioso.
Objetivo del estudio:
- Para investigar el papel de la notocorda en el desarrollo de la placa del suelo.
- Para determinar si la notocorda proporciona señales esenciales para la diferenciación de la placa del suelo.
Principales métodos:
- Utilizó un quimioatractor específico de la placa del suelo como marcador molecular.
- Realizó experimentos relacionados con la colocación ectópica de la notocorda y la extracción de la notocorda en embriones aviares.
Principales resultados:
- La expresión de quimioatractores inducida por la notocorda ectópica en las células laterales de la placa/tubo neural.
- La extirpación del notocordio impidió la expresión de quimioatractores en las células del tubo neural de la línea media.
Conclusiones:
- Una señal local procedente de la notocorda es esencial para inducir las características funcionales de la placa del suelo.
- El notocordo juega un papel inductivo crítico en el desarrollo de la placa del suelo.
Videos de Conceptos Relacionados
01:56Gastrulation
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
01:30Neurulation
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
01:51Determination
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
02:13Determining the Plane of Cell Division
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
01:41Non-Canonical Wnt Signaling Pathways
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...