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The Periodic Table and Organismal Elements01:27

The Periodic Table and Organismal Elements

Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
The Periodic Table and Organismal Elements00:57

The Periodic Table and Organismal Elements

OverviewElements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally-occurring, and fewer still are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.The Periodic Table Provides Information...
Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
Types of Toxins01:36

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Minerals01:26

Minerals

Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...

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Updated: May 24, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

El selenio y la salud humana.

Margaret P Rayman1

  • 1Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK. m.rayman@surrey.ac.uk

Lancet (London, England)
|March 3, 2012
PubMed
Resumen

El selenio es vital para la salud, afectando la inmunidad, la reproducción y la función tiroidea. Sin embargo, la suplementación puede dañar a aquellos con niveles adecuados de selenio, destacando un beneficio para la salud en forma de U.

Área de la Ciencia:

  • La bioquímica es la bioquímica.
  • Salud de las personas Salud humana Salud humana Salud humana.
  • Ciencias de la Nutrición Ciencias de la Nutrición

Sus antecedentes:

  • El selenio es parte integral de las selenoproteínas, influyendo en la producción de antioxidantes, antiinflamatorios y hormonas tiroideas.
  • Descubrimientos recientes vinculan los polimorfismos genéticos de la selenoproteína con las enfermedades, subrayando la importancia del selenio para la salud.
  • El bajo estado de selenio se asocia con un aumento de la mortalidad, el deterioro de la inmunidad y el deterioro cognitivo.

Objetivo del estudio:

  • Revisar los efectos pleiotrópicos del selenio y su papel en varios resultados de salud.
  • Examinar la asociación entre el estado de selenio y los riesgos de enfermedades crónicas, incluidos el cáncer y la diabetes.
  • Para aclarar la relación en forma de U entre el estado de selenio y los beneficios para la salud o efectos adversos.

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Principales métodos:

  • Revisión de la literatura de estudios sobre las funciones bioquímicas del selenio.
  • Análisis de datos epidemiológicos que relacionan el estado del selenio con el riesgo de enfermedad.
  • Evaluación de los hallazgos de ensayos clínicos sobre la suplementación con selenio.

Principales resultados:

  • El estado adecuado de selenio es crucial para la función inmune, la reproducción y la salud de la tiroides, con posibles efectos antivirales.
  • Un estado de selenio más alto puede reducir el riesgo de ciertos cánceres, pero los resultados de los ensayos son mixtos.
  • La suplementación de selenio en individuos con una ingesta adecuada puede aumentar el riesgo de diabetes tipo 2.

Conclusiones:

  • Los efectos del selenio en la salud muestran una curva de dosis-respuesta en forma de U, enfatizando el estado sobre la suplementación.
  • Las personas con niveles adecuados o altos de selenio deben evitar la suplementación debido a los posibles efectos adversos.
  • El mantenimiento del estado óptimo de selenio es clave, y la suplementación solo es beneficiosa para aquellos con deficiencia documentada.