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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

Las enzimas modificadoras de la cromatina como moduladores de la reprogramación.

Tamer T Onder1, Nergis Kara, Anne Cherry

  • 1Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Manton Center for Orphan Disease Research, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA.

Nature
|March 6, 2012
PubMed
Resumen

Los investigadores identificaron enzimas específicas modificadoras de la cromatina que influyen en la generación de células madre pluripotentes inducidas (iPSC). La inhibición de DOT1L, una histona metiltransferasa, aceleró la reprogramación y aumentó el rendimiento de iPSC, ofreciendo una nueva estrategia para una producción eficiente de iPSC.

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