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Updated: May 24, 2026

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Mejora la epimerización de aminoácidos glicosilados durante la síntesis de péptidos en fase sólida

Yalong Zhang1, Saddam M Muthana, David Farnsworth

  • 1Chemical Biology Laboratory, National Cancer Institute, 376 Boyles Street, Building 376, Frederick, Maryland 21702, USA.

Journal of the American Chemical Society
|March 7, 2012
PubMed
Resumen

La síntesis de glicopéptidos es un reto debido a la epimerización durante el acoplamiento. El uso de 2,4,6-trimetilpiridina (TMP) como base mejora significativamente la eficiencia de la síntesis de glicopéptidos y reduce la epimerización no deseada.

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