Video Experimental Relacionado
Updated: May 24, 2026
10:04
Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
Published on: August 1, 2025
Convertir las terapias contra el cáncer en curas: lecciones de las enfermedades infecciosas
Michael S Glickman1, Charles L Sawyers
1Infectious Diseases Service and Immunology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. glickmam@mskcc.org
Cell
|March 20, 2012
Resumen
La resistencia a los medicamentos contra el cáncer refleja los desafíos de las enfermedades infecciosas. La combinación de terapias y la orientación de las células persistentes son clave para superar el fracaso del tratamiento y prevenir la recaída en ambos campos.
Área de la Ciencia:
- Oncología Oncología.
- Enfermedades infecciosas Enfermedades infecciosas.
- Farmacología Farmacología.
Sus antecedentes:
- El desarrollo de fármacos contra el cáncer se ha desplazado hacia terapias dirigidas, pero las respuestas temporales y la resistencia a los medicamentos siguen siendo desafíos significativos.
- La resistencia a los medicamentos es una de las principales causas de fracaso del tratamiento tanto en el cáncer como en las enfermedades infecciosas, lo que hace necesarias nuevas estrategias terapéuticas.
- Comprender los mecanismos de resistencia en las enfermedades infecciosas ofrece información valiosa para mejorar la terapia del cáncer.
Objetivo del estudio:
- Para comparar y contrastar los mecanismos de resistencia a los medicamentos en el cáncer y las enfermedades infecciosas.
- Explorar cómo las estrategias utilizadas contra las infecciones virales y bacterianas pueden informar el tratamiento del cáncer.
- Identificar enfoques para eliminar las células persistentes tolerantes a los fármacos y las células iniciadoras de tumores para prevenir la recaída.
Principales métodos:
- Análisis comparativo de los mecanismos de resistencia en el cáncer y las enfermedades infecciosas.
- Revisión de las estrategias terapéuticas para superar el VIH y la tuberculosis.
- Discusión de la terapia de combinación sinérgica y la orientación de las células persistentes / células madre.
Principales resultados:
- El cáncer y las enfermedades infecciosas comparten desafíos análogos en el desarrollo de la resistencia a los medicamentos.
- La terapia de combinación es crucial para maximizar la respuesta inicial al tratamiento en ambos campos.
- Dirigirse a las células persistentes tolerantes a los fármacos (enfermedades infecciosas) y a las células madre iniciadoras de tumores (cáncer) es esencial para la remisión a largo plazo.
Conclusiones:
- Las lecciones aprendidas de la investigación de enfermedades infecciosas, particularmente con respecto a la terapia de combinación y la orientación de las células persistentes, pueden guiar una terapia de cáncer más racional.
- El desarrollo de fármacos para eliminar las células persistentes tolerantes a los medicamentos y las células iniciadoras de tumores es fundamental para prevenir la recaída tardía y acortar la duración del tratamiento tanto en el cáncer como en las enfermedades infecciosas.
- Un enfoque unificado para combatir la resistencia a los medicamentos en todas las disciplinas es prometedor para mejorar los resultados de los pacientes.
Más Videos Relacionados
Videos de Conceptos Relacionados
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
01:30Cancer Vaccines
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
01:29Microorganisms in Medicine and Therapeutics
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
02:18Cancer
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.