Video Experimental Relacionado
Updated: May 24, 2026
13:44
Sealable Femtoliter Chamber Arrays for Cell-free Biology
Published on: March 11, 2015
El ruido regulado en el paisaje epigenético del desarrollo y la enfermedad
Elisabet Pujadas1, Andrew P Feinberg
1Center for Epigenetics, Johns Hopkins University, 570 Rangos, 855 North Wolfe Street, Baltimore, MD 21205, USA.
Cell
|March 20, 2012
Resumen
El epigenoma regula la plasticidad celular controlando el ruido, influyendo en el desarrollo y las enfermedades. Este modelo explica el compromiso con el destino celular y ofrece nuevos conocimientos sobre la heterogeneidad del cáncer.
Área de la Ciencia:
- La epigenética es la epigenética.
- Biología celular Biología celular.
- Biología del desarrollo Biología del desarrollo.
- Mecanismos de la enfermedad Mecanismos de la enfermedad
Sus antecedentes:
- El ruido estocástico y la heterogeneidad no genética son factores clave que influyen en el comportamiento celular.
- Se sabe que los dominios de cromatina están desregulados en la enfermedad y remodelados durante el desarrollo.
- La plasticidad celular es un proceso fundamental en el desarrollo y la enfermedad.
Objetivo del estudio:
- Proponer un modelo donde el epigenoma modula la plasticidad celular mediante la regulación del ruido.
- Para explorar el papel de los dominios de cromatina en la plasticidad celular.
- Para presentar un marco matemático para el paisaje epigenético de Waddington.
Principales métodos:
- Síntesis de observaciones pasadas y presentes en epigenética.
- Discusión del ruido estocástico y la heterogeneidad no genética.
- Modelado matemático del paisaje epigenético.
Principales resultados:
- El modelo propuesto sugiere que el epigenoma facilita las transiciones de fase y la canalización durante el compromiso del destino celular.
- Distintos dominios de cromatina pueden ser la base de la plasticidad celular.
- Se presenta un formalismo matemático para el paisaje epigenético.
Conclusiones:
- La regulación del ruido por parte del epigenoma es crucial para la plasticidad celular en el desarrollo y la enfermedad.
- El nuevo marco puede afectar a la comprensión de los mecanismos de la enfermedad, en particular la heterogeneidad del cáncer.
- El aumento de la variabilidad en la metilación del ADN y la expresión génica en el cáncer podría explicarse por este modelo.
Videos de Conceptos Relacionados
01:37Epigenetic Regulation
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
01:46Epigenetic Regulation
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
01:46Epigenetic Regulation
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
02:54Nucleosome Remodeling
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
01:20Gene-Environment Interactions
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
02:30Genomic Imprinting and Inheritance
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...