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Updated: Apr 3, 2026

Harvesting and Cryo-cooling Crystals of Membrane Proteins Grown in Lipidic Mesophases for Structure Determination by Macromolecular Crystallography
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Estructura cristalina del receptor μ-opioide unido a un antagonista del morfinano

Aashish Manglik1, Andrew C Kruse, Tong Sun Kobilka

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA.

Nature
|March 23, 2012
PubMed
Resumen

Los investigadores determinaron la estructura cristalina del receptor μ-opioide (μ-OR) del ratón, revelando un bolsillo de unión único y grande y una estructura dimérica. Este hallazgo ayuda en el desarrollo de mejores tratamientos para el dolor y la adicción.

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