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El posicionamiento diferencial de las uniones de adherens se asocia con el inicio del plegamiento epitelial
Yu-Chiun Wang1, Zia Khan, Matthias Kaschube
1Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
Nature
|March 30, 2012
Resumen
El plegamiento epitelial, crucial para el desarrollo, puede ocurrir a través de un nuevo mecanismo que implica el reposicionamiento de la unión de adherencias. Este proceso está regulado por las proteínas de polaridad epitelial, ofreciendo nuevos conocimientos sobre la morfogénesis tisular.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Biología celular Biología celular.
- Genética La genética.
Sus antecedentes:
- El plegamiento epitelial es esencial para la formación de estructuras complejas durante la morfogénesis tisular.
- El modelo establecido atribuye el plegamiento epitelial a la constricción apical impulsada por la miosina.
- Se investiga un mecanismo alternativo que involucra el posicionamiento de la unión de adherencias y la polaridad epitelial.
Objetivo del estudio:
- Describir un mecanismo alternativo para el plegamiento epitelial.
- Investigar el papel del posicionamiento de la unión de las adherencias diferenciales en el plegamiento epitelial.
- Para aclarar la participación de la polaridad epitelial apical-basal en este proceso.
Principales métodos:
- Imágenes de embriones vivos en Drosophila.
- Análisis del posicionamiento de la unión de adherencias.
- Investigación de las funciones de las proteínas de polaridad Bazooka y Par-1.
- Manipulación de los niveles y la actividad de las proteínas.
Principales resultados:
- Las uniones de adherens se desplazan básicamente en las células iniciadoras durante la formación del pliegue transversal dorsal en la gastrulación de Drosophila.
- Este desplazamiento basal depende de las proteínas de polaridad Bazooka y Par-1.
- La reducción de la actividad de Bazooka o Par-1 elimina la iniciación del pliegue.
- La relación Bazooka/Par-1 alterada conduce a pliegues dorsales ectópicos.
- El desplazamiento de la unión basal deforma las formas de las células y facilita la deformación de los tejidos.
Conclusiones:
- La modificación de la polaridad epitelial influye directamente en el inicio del plegamiento epitelial.
- El posicionamiento de la unión de adherencias diferenciales es un mecanismo clave en la morfogénesis tisular.
- La vía Bazooka/Par-1 regula el posicionamiento de las uniones y el posterior plegamiento de los tejidos.
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