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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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Estructuras de la polimerasa de ADN de KlenTaq capturadas mientras se incorporan pirimidina modificada C5 y

Konrad Bergen1, Anna-Lena Steck, Stefan Strütt

  • 1Department of Chemistry, Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstr. 10, 78457 Konstanz, Germany.

Journal of the American Chemical Society
|April 6, 2012
PubMed
Resumen

Este estudio revela la base estructural de las polimerasas de ADN que aceptan nucleótidos modificados, crucial para la biotecnología. Estos hallazgos permiten el diseño racional de nuevos nucleótidos para aplicaciones avanzadas.

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