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El perfil de metabolitos identifica las vías asociadas con el riesgo metabólico en humanos
Susan Cheng1, Eugene P Rhee, Martin G Larson
1Cardiology Division, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA.
Circulation
|April 13, 2012
Resumen
Los factores de riesgo metabólicos como la obesidad están relacionados con metabolitos sanguíneos específicos. Un nivel más alto de glutamina en relación con el glutamato puede reducir el riesgo de diabetes y presión arterial, como se muestra en modelos de ratón.
Área de la Ciencia:
- La Metabolomía es una parte de la Metabolomía.
- Investigación de Enfermedades Cardiovasculares Investigación de Enfermedades Cardiovasculares
- Investigación de la diabetes mellitus Investigación de la diabetes mellitus Investigación de la diabetes mellitus Investigación de la diabetes mellitus Investigación de la diabetes mellitus Investigación de la diabetes mellitus Investigación de la diabetes mellitus Investigación de la diabetes mellitus Investigación de la diabetes mellitus Investigación de la diabetes mellitus Investigación de la diabetes mellitus Investigación de la diabetes mellitus Investigación de la diabetes mellitus
Sus antecedentes:
- Los factores de riesgo metabólicos se agrupan en individuos propensos a la diabetes y las enfermedades cardiovasculares.
- Los mecanismos biológicos subyacentes para estos grupos son poco conocidos.
Objetivo del estudio:
- Para identificar las vías metabólicas asociadas con el riesgo cardiometabólico.
- Investigar la relación entre los metabolitos plasmáticos y los factores de riesgo cardiometabólico.
Principales métodos:
- Cromatografía líquida / espectrometría de masas para medir 45 metabolitos plasmáticos.
- Análisis en el Estudio del Corazón de Framingham (FHS) y el Estudio de la Dieta y el Cáncer de Malmö (MDC).
- Interrogación de los hallazgos en modelos experimentales de enfermedades cardiovasculares y metabólicas.
Principales resultados:
- Factores de riesgo metabólicos asociados con los aminoácidos de cadena ramificada, los aminoácidos hidrofóbicos, los productos de degradación del triptófano y los metabolitos de nucleótidos.
- La resistencia a la insulina está fuertemente relacionada con la glutamina, el glutamato y la relación glutamina-glutamato.
- Una alta proporción de glutamina-glutamato está asociada con un menor riesgo de incidencia de diabetes en FHS.
- La administración de glutamina en ratones mejoró la tolerancia a la glucosa y disminuyó la presión arterial.
Conclusiones:
- El perfil bioquímico identificó nuevos metabolitos circulantes asociados con rasgos metabólicos.
- El exceso de glutamina en relación con el glutamato, por administración exógena, reduce el riesgo metabólico en ratones.
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