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Evolución de una globina polimérica en el camarón de salmuera Artemia
A M Manning1, C N Trotman, W P Tate
1Department of Biochemistry, University of Otago, Dunedin, New Zealand.
Nature
|December 13, 1990
Resumen
Los invertebrados como el camarón de salmuera tienen hemoglobinas poliméricas formadas por genes de globina fusionada. El análisis revela que estos genes codifican múltiples dominios funcionales, lo que sugiere antiguos eventos de fusión génica en la evolución de la hemoglobina.
Área de la Ciencia:
- La bioquímica es la bioquímica.
- Biología evolutiva Biología evolutiva.
- Biología Molecular Biología Molecular
Sus antecedentes:
- Los invertebrados exhiben diversas estructuras de hemoglobina, incluidas formas poliméricas con múltiples dominios de unión al hemo por polipéptido.
- Estas hemoglobinas poliméricas pueden surgir de la fusión de genes ancestrales de globinas monoméricas.
Objetivo del estudio:
- Para analizar la transcripción de un gen de globina polimérica del camarón de salmuera Artemia.
- Para dilucidar la estructura y el origen evolutivo de las hemoglobinas poliméricas de Artemia.
Principales métodos:
- Análisis de clones de ADN complementario (ADNc) que codifican las subunidades de la hemoglobina dimérica de Artemia.
- Análisis bioinformático de secuencias de aminoácidos derivados para predecir la estructura de las proteínas y la historia evolutiva.
Principales resultados:
- El ARN mensajero de globina de Artemia codifica nueve dominios parecidos a la mioglobina vinculados por secuencias específicas de péptidos.
- Cada dominio contiene residuos de unión al hemo conservados y se prevé que adopten un pliegue similar al de la mioglobina.
- El análisis de secuencias sugiere que estos dominios son monómeros duplicados que se fusionaron hace aproximadamente 200 millones de años.
Conclusiones:
- El gen de globina polimérica en Artemia evolucionó a través de la fusión de múltiples unidades de globina ancestrales.
- La fusión génica es un mecanismo probable para la aparición de hemoglobinas poliméricas en los invertebrados.
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