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Se requiere un eje PPARγ-FGF1 para la remodelación adiposa adaptativa y la homeostasis metabólica
Johan W Jonker1, Jae Myoung Suh, Annette R Atkins
1Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
Nature
|April 24, 2012
Resumen
El factor de crecimiento de fibroblastos 1 (FGF1) es crucial para la remodelación del tejido adiposo y la homeostasis metabólica. Su regulación por PPARγ es vital para prevenir la diabetes y la disfunción del tejido adiposo bajo dietas altas en grasas.
Área de la Ciencia:
- La homeostasis metabólica también se llama homeostasis metabólica.
- Biología del tejido adiposo Biología del tejido adiposo
- Endocrinología Endocrinología.
Sus antecedentes:
- La remodelación del tejido adiposo es esencial para la homeostasis metabólica durante las fluctuaciones de los nutrientes.
- Los mecanismos que regulan la adaptación del tejido adiposo siguen siendo poco conocidos.
- El factor de crecimiento de fibroblastos 1 (FGF1) está implicado en varios procesos fisiológicos.
Objetivo del estudio:
- Identificar los reguladores críticos de la remodelación del tejido adiposo en respuesta a la disponibilidad de nutrientes.
- Para investigar el papel de FGF1 en la homeostasis metabólica y la sensibilización a la insulina.
- Para aclarar la relación reguladora entre FGF1 y PPARγ en el tejido adiposo.
Principales métodos:
- Utilizó ratones knockout FGF1 y desafíos de dieta alta en grasas.
- Se analizó la histopatología del tejido adiposo, la vasculatura, la inflamación y las características de los adipocitos.
- Investigó la regulación transcripcional de FGF1 por PPARγ utilizando un elemento de respuesta PPAR.
Principales resultados:
- Los ratones knockout FGF1 exhiben un fenotipo diabético agresivo y una expansión adiposa aberrante en una dieta alta en grasas.
- La deficiencia de FGF1 conduce a patologías vasculares del tejido adiposo, inflamación y necrosis de la grasa.
- PPARγ regula directamente la inducción de FGF1 en el tejido adiposo a través de un elemento de respuesta PPAR.
Conclusiones:
- El eje PPARγFGF1 es crítico para mantener la homeostasis metabólica y la sensibilidad a la insulina.
- FGF1 juega un papel vital en la adaptación del tejido adiposo a los desafíos dietéticos.
- La desregulación de la vía PPARγFGF1 contribuye a la enfermedad metabólica inducida por la dieta.
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