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La vía de señalización GSK3-TIP60-ULK1 vincula la privación del factor de crecimiento con la autofagia

Shu-Yong Lin1, Terytty Yang Li, Qing Liu

  • 1State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.

Science (New York, N.Y.)
|April 28, 2012
PubMed
Resumen

La privación del factor de crecimiento desencadena la autofagia a través de una nueva vía. La glucógeno sintetasa quinasa-3 (GSK3) activa el TIP60, que acetila y estimula el ULK1, iniciando así la autofagia.

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