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La ingeniería de la tercera ola de biocatálisis
U T Bornscheuer1, G W Huisman, R J Kazlauskas
1Institute of Biochemistry, Department of Biotechnology & Enzyme Catalysis, Greifswald University, Felix-Hausdorff-Straße 4, D-17487 Greifswald, Germany. uwe.bornscheuer@uni-greifswald.de
Nature
|May 12, 2012
Resumen
La biocatálisis, utilizando enzimas de ingeniería, ofrece una alternativa ecológica a la síntesis química tradicional. Los avances en la ingeniería de proteínas permiten nuevas aplicaciones de enzimas desde productos químicos hasta productos farmacéuticos.
Área de la Ciencia:
- Biocatálisis y química sintética.
Sus antecedentes:
- La biocatálisis ha surgido como una alternativa sostenible a la síntesis química tradicional en la última década.
- Los avances en la secuenciación del ADN y la síntesis de genes han impulsado el progreso en la ingeniería de proteínas y el diseño de enzimas.
- Las enzimas diseñadas pueden reorganizarse en nuevas vías biosintéticas.
Objetivo del estudio:
- Para resaltar los logros en la biocatálisis impulsada por la ingeniería de proteínas.
- Para discutir las diversas aplicaciones de los biocatalizadores de ingeniería.
Principales métodos:
- Ingeniería de proteínas y diseño de biocatalizadores.
- Desarrollo de nuevas vías biosintéticas.
- Aplicación de la catálisis enzimática en la síntesis química.
Principales resultados:
- Biocatálisis práctica y respetuosa con el medio ambiente para la síntesis química industrial y de laboratorio.
- Biocatalizadores personalizados a través de técnicas avanzadas de ingeniería de proteínas.
- Reorganizó con éxito las enzimas en nuevas vías biosintéticas.
Conclusiones:
- Los biocatalizadores de ingeniería proteica son una alternativa viable y ecológica en la síntesis química.
- La catálisis enzimática es un paso clave en la producción de productos químicos básicos y productos intermedios farmacéuticos.
- Los continuos avances en biotecnología están expandiendo el alcance del biocatálisis.
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