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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
La lesión renal aguda es una lesión renal aguda
Rinaldo Bellomo1, John A Kellum, Claudio Ronco
1Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. rinaldo.bellomo@austin.org.au
Lancet (London, England)
|May 24, 2012
Resumen
La lesión renal aguda (IRA) es una disminución rápida de la función renal, que a menudo ocurre en pacientes hospitalizados. Si bien AKI se puede revertir, aumenta significativamente el riesgo de desarrollar enfermedad renal crónica más adelante en la vida.
Área de la Ciencia:
- Nefrología Nefrología.
- Medicina de cuidados críticos Medicina de cuidados críticos.
Sus antecedentes:
- La lesión renal aguda (IRA) se caracteriza por la pérdida rápida de la función excretora renal.
- Es una complicación común en pacientes hospitalizados y en estado crítico, a menudo derivada de factores externos.
- El tratamiento actual para AKI es principalmente de apoyo, sin terapias específicas para revertir o acelerar la recuperación.
Objetivo del estudio:
- Para resumir la comprensión actual de la lesión renal aguda.
- Para resaltar los desafíos de diagnóstico y las técnicas emergentes.
- Para discutir las modalidades de tratamiento y los resultados a largo plazo.
Principales métodos:
- Revisión de la literatura existente sobre la lesión renal aguda.
- Análisis de los criterios de diagnóstico y las manifestaciones clínicas.
- Examen de las estrategias de tratamiento y los resultados de los pacientes.
Principales resultados:
- AKI se diagnostica por marcadores como urea elevada y creatinina o reducción de la producción de orina.
- Los eventos extrarrenales son causas frecuentes en pacientes en estado crítico, aunque los mecanismos siguen siendo objeto de debate.
- La terapia de reemplazo renal se utiliza para los casos graves de IAC.
- La recuperación a la independencia de la diálisis es típica para los sobrevivientes sin enfermedad renal crónica preexistente.
Conclusiones:
- El diagnóstico temprano a través de nuevos biomarcadores renales puede mejorar los resultados de los pacientes.
- Los sobrevivientes de AKI se enfrentan a un riesgo elevado de desarrollar enfermedad renal crónica.
- Se necesita más investigación para comprender la patogénesis de AKI y desarrollar terapias dirigidas.
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