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La eficiencia de importación mitocondrial de ATFS-1 regula la activación de la UPR mitocondrial

Amrita M Nargund1, Mark W Pellegrino, Christopher J Fiorese

  • 1Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Science (New York, N.Y.)
|June 16, 2012
PubMed
Resumen

Las células sienten el estrés mitocondrial mediante la regulación de la importación de la proteína ATFS-1 en las mitocondrias. La reducción de la importación permite a ATFS-1 señalar al núcleo, activando una respuesta protectora.

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