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Ingeniería de virus de la gripe aviar H5N1 para estudiar la adaptación humana

David M Morens¹, Kanta Subbarao, Jeffery K Taubenberger

¹National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. dm270q@nih.gov

|June 23, 2012

Resumen

Los estudios controvertidos sobre la influenza aviar H5N1 transmisible en hurones plantean preocupaciones sobre la investigación de doble uso. Continúan los debates sobre la publicación y el equilibrio entre el progreso científico y los riesgos de bioseguridad.

Área de la Ciencia:

Virología Virología.
Enfermedades infecciosas Enfermedades infecciosas.
Bioseguridad La bioseguridad.

Sus antecedentes:

Los virus de la gripe aviar H5N1 genéticamente modificados fueron creados para estudiar la transmisión entre hurones.
Estos estudios han generado una controversia significativa debido a las posibles implicaciones de la investigación de doble uso.

Objetivo del estudio:

Para investigar la transmisibilidad de los virus de la gripe aviar H5N1 modificados.
Para abordar las preocupaciones éticas y de seguridad que rodean la investigación de la ganancia de función en la influenza.

Principales métodos:

Ingeniería genética de los virus de la gripe aviar H5N1.
Estudios de transmisión en modelos de hurones.

Principales resultados:

Los virus modificados demostraron la capacidad de transmisión entre hurones.
Surgieron opiniones divergentes con respecto a la importancia y los riesgos de la investigación.

Conclusiones:

No existe consenso sobre cómo equilibrar los beneficios de dicha investigación con sus riesgos potenciales.
El debate sobre la publicación y la regulación de la investigación de la gripe de ganancia de función continúa.

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