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Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
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Una vía de silenciamiento epigenético que controla el compromiso de la línea celular T ayudante 2 con el linaje

Rhys S Allan1, Elina Zueva, Florence Cammas

  • 1Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France.

Nature
|July 6, 2012
PubMed
Resumen

La vía SUV39H1H3K9me3HP1α mantiene la estabilidad de las células T ayudante 2 (TH2) al silenciar los genes T ayudante 1 (TH1). La pérdida de esta vía promueve las respuestas TH1 y exacerba el asma alérgica.

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