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Malleilactona, un factor de virulencia derivado de la policetida sintasa codificado por el metaboloma secundario

John B Biggins1, Melinda A Ternei, Sean F Brady

  • 1Laboratory of Genetically Encoded Small Molecules, The Rockefeller University and Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10068, USA.

Journal of the American Chemical Society
|July 7, 2012
PubMed
Resumen

Los investigadores descubrieron un grupo de genes silenciosos en los patógenos de Burkholderia que produce una toxina llamada malleilactona. La activación de este racimo debilitó las bacterias, lo que sugiere que la maleilactona es un objetivo terapéutico para la melioidosis y las glándulas.

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