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Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies
Published on: August 29, 2017
Los anticuerpos ampliamente neutralizantes presentan nuevas perspectivas para contrarrestar los virus de alta
Dennis R Burton1, Pascal Poignard, Robyn L Stanfield
1Department of Immunology and Microbial Science and International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. burton@scripps.edu
Science (New York, N.Y.)
|July 17, 2012
Resumen
Los virus altamente diversos como el VIH evaden la inmunidad mediante la mutación de proteínas superficiales. Sin embargo, la orientación de sitios conservados con anticuerpos ampliamente neutralizantes ofrece esperanzas para nuevas vacunas y medicamentos.
Área de la Ciencia:
- Virología Virología.
- Inmunología Inmunología.
- Vacunología Vacunología.
Sus antecedentes:
- Ciertos patógenos humanos, incluidos los virus del VIH, la gripe y la hepatitis C, exhiben una alta diversidad antigénica.
- Esta diversidad les permite evadir la detección del sistema inmunológico mediante la rápida mutación de las proteínas superficiales dirigidas por los anticuerpos.
- Esto plantea desafíos significativos para el desarrollo de vacunas.
Objetivo del estudio:
- Explorar el potencial de dirigirse a sitios de proteínas superficiales conservadas en virus altamente antigénicamente diversos.
- Investigar el papel de los anticuerpos ampliamente neutralizantes en la lucha contra estos patógenos difíciles.
- Evaluar las implicaciones de los avances recientes en la identificación y caracterización de anticuerpos para el descubrimiento de vacunas y medicamentos.
Principales métodos:
- Identificación y caracterización de anticuerpos ampliamente neutralizantes.
- Análisis molecular de los sitios de reconocimiento de anticuerpos en las proteínas de la superficie viral.
- Análisis de las estrategias de mutación viral para evadir las respuestas inmunes.
Principales resultados:
- Los virus de alta diversidad antigénica poseen sitios expuestos conservados cruciales para su función.
- Estos sitios conservados pueden ser atacados por anticuerpos ampliamente neutralizantes.
- Los avances en la identificación y caracterización de estos anticuerpos han aumentado.
Conclusiones:
- Dirigirse a sitios funcionales conservados con anticuerpos ampliamente neutralizantes presenta una estrategia prometedora para desarrollar vacunas contra virus muy diversos.
- La investigación adicional sobre estos anticuerpos y sitios vulnerables puede conducir a nuevas intervenciones terapéuticas.
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