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La oxitrifluorometilación catalizada por el cobre de alquenos no activados
1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Journal of the American Chemical Society
|July 19, 2012
Resumen
Un nuevo método catalizado por cobre agrega de manera eficiente grupos trifluorometilo a los alquenos. Esta técnica versátil crea compuestos útiles que contienen CF3 a partir de materiales de partida simples.
Área de la Ciencia:
- Química orgánica es la química orgánica.
- La catálisis de la catálisis.
- Química del flúor Química del flúor
Sus antecedentes:
- Los compuestos que contienen trifluorometilo (CF(3) son importantes en los productos farmacéuticos y en la ciencia de los materiales.
- Los métodos eficientes para la introducción de los grupos CF ((3) son muy buscados.
- Los métodos existentes a menudo requieren condiciones duras o reactivos especializados.
Objetivo del estudio:
- Desarrollar un método suave, versátil y conveniente para la oxitrifluorometilación de alquenos no activados.
- Para utilizar una estrategia de difuncionalización oxidativa catalizada por el cobre.
- Proporcionar acceso a los bloques de construcción que contienen CF ((3) sintéticamente útiles.
Principales métodos:
- Difuncionalización oxidativa catalizada por el cobre.
- Reacción de alquenos no activados con una fuente de trifluorometil y un oxidante.
- Condiciones de reacción leves. condiciones de reacción leves.
Principales resultados:
- Eficaz oxitrifluorometilación de una gama de alquenos no activados.
- Síntesis exitosa de varios bloques de construcción que contienen CF.
- Demostración de una metodología versátil y conveniente.
Conclusiones:
- Se ha establecido un método nuevo y eficiente para la oxitrifluorometilación de alceno.
- La estrategia desarrollada ofrece una valiosa ruta a los compuestos que contienen CF.
- Esta metodología amplía el conjunto de herramientas para sintetizar moléculas de organofluoruro.
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