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Videos de Conceptos Relacionados

Chromatin Packaging01:32

Chromatin Packaging

Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
Chromatin Packaging02:21

Chromatin Packaging

Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order structures.
The DNA Helix01:16

The DNA Helix

Overview
The DNA Helix01:07

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
The Nucleosome01:19

The Nucleosome

Human DNA is almost two meters long. However, it is compressed inside a tiny nucleus measuring only a few microns in diameter. To make this degree of compaction possible, DNA is organized into several sequential levels so that it can fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
In a chromosome, DNA is wound twice around a protein complex called a histone octamer core, which consists of 8 histone proteins. This...
The Nucleosome02:33

The Nucleosome

DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA inside the nucleus is astonishing. It is organized into several sequentially higher levels of compaction to fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...

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Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
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Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

El transporte de carga dentro de un marco tridimensional de la nanoestructura del ADN.

Na Lu1, Hao Pei, Zhilei Ge

  • 1Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.

Journal of the American Chemical Society
|July 20, 2012
PubMed
Resumen
Este resumen es generado por máquina.

Este estudio explora el transporte de carga mediado por el ADN (TC) en nanoestructuras de ADN 3D. Revela vías distintas para diferentes moléculas, avanzando en la electrónica molecular basada en el ADN y el diseño de biosensores.

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Área de la Ciencia:

  • Biología Molecular Biología Molecular
  • Nanotecnología La nanotecnología es la nanotecnología.
  • La biofísica es la biofísica.

Sus antecedentes:

  • Las nanoestructuras tridimensionales (3D) de ADN ofrecen potencial en la detección molecular y la terapéutica.
  • La comprensión de los mecanismos de transporte de carga (CT) dentro de estas estructuras es crucial para el desarrollo de dispositivos electrónicos avanzados.

Objetivo del estudio:

  • Para investigar la cinética del transporte de carga mediado por el ADN (TC) dentro de una nanoestructura de ADN 3D.
  • Para diferenciar entre los mecanismos de TC a través del dúplex y a través del espacio utilizando sondas redox específicas.

Principales métodos:

  • Utilizó un marco de nanoestructura de ADN tetraédrico.
  • Se estudió el transporte de carga de las moléculas redox de azul de metileno (MB) y ferroceno (Fc).
  • Tasas de TC medidas para moléculas unidas a posiciones específicas en una superficie de electrodo de oro.

Principales resultados:

  • Se ha demostrado una TC mediada eficiente en distancias más largas a lo largo del dúplex de ADN para la sonda MB intercalativa.
  • Se demostró que la sonda Fc no intercalativa se somete a un túnel de electrones a través del espacio.
  • Proporcionó datos cinéticos que distinguen las vías de TC basadas en las características de la sonda molecular.

Conclusiones:

  • El estudio aclara distintos mecanismos de transporte de carga dentro de las nanoestructuras de ADN 3D.
  • Los hallazgos contribuyen a la comprensión de la electrónica molecular basada en el ADN.
  • Proporciona información para el diseño de dispositivos biosensores de ADN de alto rendimiento.