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Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...

Mechanically-gated Ion Channels

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Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...

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Position-effect Variegation

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Design and Synthesis of a Reconfigurable DNA Accordion Rack

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Un interruptor de ADN mecánico-electrónico.

Jason M Thomas¹, Hua-Zhong Yu, Dipankar Sen

¹Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6.

Journal of the American Chemical Society

|July 28, 2012

Resumen

Este resumen es generado por máquina.

Desarrollamos una nueva nanomaquina de ADN que utiliza iones de mercurio (Hg2+) para controlar el movimiento mecánico y el transporte de carga de ADN. Este interruptor de ADN activado por mercurio enlaza el movimiento físico con las señales electrónicas, lo que permite nuevas capacidades de monitoreo de nanodispositivos.

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Área de la Ciencia:

* La nanotecnología * La nanotecnología
* Biología Molecular.
* La biofísica es la biofísica.

Sus antecedentes:

* Las nanomáquinas de ADN ofrecen potencial para dispositivos a nanoescala.
* El control del movimiento mecánico y las propiedades electrónicas en las nanoestructuras de ADN es un desafío clave.

Objetivo del estudio:

* Para diseñar una nanomáquina de ADN que acople el movimiento mecánico para cargar el transporte utilizando iones de mercurio.
* Para demostrar un interruptor mecánico-electrónico basado en el ADN que puede ser monitoreado electrónicamente.

Principales métodos:

* Construcción de una nanomáquina de ADN de unión helicoidal de tres vías con un dominio de unión de mercurio.
* Pruebas de huella química y análisis de oxidación de guanina para monitorear el transporte de cargas.
* Förster Transferencia de Energía de Resonancia (FRET) para rastrear movimientos mecánicos.

Principales resultados:

* El mercurio (Hg2+) que se une a los desajustes T-T formó pares de bases T-Hg2+-T, mejorando significativamente el transporte de carga.
* La unión/disociación de Hg2+ está directamente correlacionada con los movimientos mecánicos de los tallos de ADN.
* El transporte de carga mejorado se relacionó con los tallos que se mueven de una conformación doblada a una conformación lineal, apilada coaxialmente.

Conclusiones:

* Se creó una nueva nanomaquina de ADN que traduce la unión del mercurio en movimiento mecánico y transporte de carga alterado.
* Este conmutador de ADN activado por mercurio proporciona un paradigma para monitorear el trabajo mecánico de los nanodispositivos a través de mediciones electrónicas.