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Videos de Conceptos Relacionados

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
Complexometric Titration: Ligands00:43

Complexometric Titration: Ligands

Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
Properties of Organometallic Compounds01:23

Properties of Organometallic Compounds

Organometallic compounds are compounds that contain a carbon–metal bond. Carbon belongs to an organyl group like alkyl, aryl, allyl, or benzyl groups. The metal can be from Group I or Group II of the periodic table, a transition metal, or a semimetal.

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Synthesis of a Water-soluble Metal–Organic Complex Array
06:40

Synthesis of a Water-soluble Metal–Organic Complex Array

Published on: October 8, 2016

Metalosomas poliméricos bioactivos autoensamblados a través de la complejación copolímero-metal en bloque.

Kensuke Osada1, Horacio Cabral, Yuki Mochida

  • 1Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

Journal of the American Chemical Society
|July 28, 2012
PubMed
Resumen

Los investigadores desarrollaron nuevos metalosomas poliméricos utilizando un medicamento contra el cáncer y un copolímero de bloque. Estas estructuras autoensambladas entregan eficazmente fármacos a los tumores y permiten la obtención de imágenes fluorescentes, mostrando una promesa como portadores de fármacos multifuncionales.

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Área de la Ciencia:

  • Ciencia de los Biomateriales Ciencia de los Biomateriales.
  • Nanotecnología La nanotecnología es la nanotecnología.
  • Química de Polímeros La Química de Polímeros es la química de los polímeros.

Sus antecedentes:

  • Los metalosomas poliméricos ofrecen potencial para la administración de fármacos dirigidos.
  • El desarrollo de nanoestructuras autoensambladas con liberación controlada de fármacos es crucial para la terapia del cáncer.

Objetivo del estudio:

  • Para investigar la formación espontánea de los metalosomas poliméricos.
  • Para evaluar su potencial para la administración de fármacos y la obtención de imágenes tumorales.

Principales métodos:

  • Reacción de (1,2-diaminociclohexano) platino (II) (DACHPt) con un copolímero de bloque en forma de Y (PEGasus-PLGA-Chole).
  • Caracterización mediante espectroscopia de dicroísmo circular.
  • Estudios in vivo en ratones para la administración de fármacos y imágenes de tumores.

Principales resultados:

  • Metalosomas poliméricos uniformes (~100 nm) se formaron espontáneamente en el medio acuoso.
  • El segmento PLGA adoptó una estructura de hélice α, impulsando el autoensamblaje en estructuras vesiculares.
  • Los metalosomas encapsularon con éxito las macromoléculas, las entregaron a los tumores y permitieron la obtención de imágenes fluorescentes con actividad antitumoral demostrada.

Conclusiones:

  • Los metalosomas poliméricos autoensamblados muestran potencial como portadores de fármacos multifuncionales.
  • El sistema facilita la administración dirigida de agentes anticancerígenos y agentes de imagen a los tumores.
  • La formación de la estructura secundaria del segmento PLGA juega un papel clave en el proceso de autoensamblaje.