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Remodelación del microbioma intestinal del huésped y cambios metabólicos durante el embarazo
Omry Koren1, Julia K Goodrich, Tyler C Cullender
1Department of Microbiology, Cornell University, Ithaca, NY 14853, USA.
Cell
|August 7, 2012
Resumen
El embarazo altera las bacterias intestinales, aumentando la inflamación y los signos de pérdida de energía en el tercer trimestre. Esta microbiota alterada, cuando se transfiere a los ratones, causa un aumento de la adiposidad y la insensibilidad a la insulina, lo que sugiere un papel en el metabolismo del huésped.
Área de la Ciencia:
- Microbiología Microbiología.
- Inmunología Inmunología.
- Salud Metabólica La salud metabólica es la salud metabólica.
Sus antecedentes:
- El embarazo comparte cambios inmunológicos y metabólicos con el síndrome metabólico.
- La microbiota intestinal puede inducir síntomas del síndrome metabólico en personas no embarazadas.
Objetivo del estudio:
- Para investigar el papel de la microbiota intestinal durante el embarazo.
- Para caracterizar las bacterias fecales en mujeres embarazadas y sus bebés.
Principales métodos:
- Se analizaron bacterias fecales de 91 mujeres embarazadas y sus bebés.
- Se comparó la composición y la diversidad de la microbiota entre trimestres (T1 y T3).
- La microbiota de T1 y T3 se transfirió a ratones libres de gérmenes para evaluar el impacto metabólico.
Principales resultados:
- La composición de la microbiota intestinal cambió significativamente del primer al tercer trimestre.
- La microbiota del tercer trimestre mostró un aumento de Proteobacteria y Actinobacteria, una riqueza reducida y signos de inflamación y pérdida de energía.
- La transferencia de la microbiota del tercer trimestre a los ratones condujo a una mayor adiposidad e insensibilidad a la insulina en comparación con la microbiota del primer trimestre.
Conclusiones:
- Las interacciones huésped-microbios durante el embarazo impactan significativamente el metabolismo del huésped.
- Los cambios en la microbiota intestinal durante el embarazo pueden contribuir a las alteraciones metabólicas.
- Estas interacciones huésped-microbiana podrían ser beneficiosas durante el embarazo.
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