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Updated: May 19, 2026

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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Published on: April 4, 2025

El G-cuadruplex mayor formado en el promotor β del receptor del factor de crecimiento derivado de las plaquetas

Yuwei Chen1, Prashansa Agrawal, Robert V Brown

  • 1Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 East Mabel Street, Tucson, Arizona 85721, USA.

Journal of the American Chemical Society
|August 8, 2012
PubMed
Resumen

Los investigadores identificaron una nueva estructura de ADN G-cuadruplex en el promotor del gen del receptor del factor de crecimiento β (PDGFR-β) derivado de las plaquetas. Esta estructura única, con una hebra G rota, ofrece un nuevo objetivo para el desarrollo de fármacos para tratar los cánceres asociados con PDGFR-β y los trastornos fibróticos.

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