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Diabetes y hipertensión: los malos compañeros
Ele Ferrannini1, William C Cushman
1Department of Internal Medicine, University of Pisa, Pisa, Italy. ferranni@ifc.cnr.it
Lancet (London, England)
|August 14, 2012
Resumen
La presión arterial alta es común en la diabetes tipo 2, relacionada con la hiperglucemia. El control de la presión arterial es crucial para reducir el riesgo cardiovascular en pacientes diabéticos.
Área de la Ciencia:
- Endocrinología Endocrinología.
- Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
- Nefrología Nefrología.
Sus antecedentes:
- Más de dos tercios de los pacientes con diabetes tipo 2 tienen presión arterial alta.
- La hipertensión en la diabetes aumenta significativamente el riesgo de enfermedad cardiovascular.
- La hiperglucemia y la hipertensión comparten vías fisiopatológicas comunes.
Objetivo del estudio:
- Explorar los mecanismos fisiopatológicos que vinculan la diabetes tipo 2 y la hipertensión.
- Establecer metas terapéuticas de presión arterial para pacientes diabéticos.
- Recomendar estrategias antihipertensivas óptimas para las personas con diabetes.
Principales métodos:
- Revisión de los mecanismos fisiopatológicos que conectan la diabetes y la hipertensión.
- Análisis de la evidencia de ensayos clínicos para objetivos de presión arterial.
- Evaluación de las clases de medicamentos antihipertensivos y sus efectos.
Principales resultados:
- Los mecanismos plausibles incluyen la resistencia a la insulina, los efectos de la hiperinsulinemia y el impacto de la hiperglucemia en el sistema renina-angiotensina-aldosterona.
- Se recomienda un objetivo de presión arterial por debajo de 140/85 mm Hg para pacientes con diabetes tipo 2.
- Los bloqueadores del sistema renina-angiotensina con diuréticos tiazídicos pueden ser un régimen inicial preferido.
- Los medicamentos antihipertensivos generalmente muestran beneficios cardiovasculares positivos que exceden los impactos negativos en el metabolismo de la glucosa.
Conclusiones:
- Comprender la interacción entre la diabetes, la hiperglucemia y la hipertensión es clave.
- El manejo agresivo de la presión arterial es vital para la protección cardiovascular en la diabetes tipo 2.
- Las combinaciones antihipertensivas específicas ofrecen un control efectivo de la presión arterial con efectos metabólicos manejables.
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