Search research articles

ACERCA DE JoVE

Visión General Liderazgo Blog Centro de Ayuda JoVE

AUTORES

Proceso de Publicación Consejo Editorial Alcance y Políticas Revisión por Pares Preguntas Frecuentes Enviar

BIBLIOTECARIOS

Testimonios Suscripciones Acceso Recursos Consejo Asesor de Bibliotecas Preguntas Frecuentes

INVESTIGACIÓN

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archivo

EDUCACIÓN

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Centro de Recursos para Profesores Sitio de Profesores

Términos y Condiciones de Uso

Política de Privacidad

Videos de Conceptos Relacionados

Endocrine Signaling

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.

Hedgehog Signaling Pathway

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

Overview of Cell Signaling

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...

Hedgehog Signaling Pathway

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

Chemical Signaling in the Endocrine System

Chemical Signaling in the Endocrine System

A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por

Same author

Dachsous-Fat signaling shapes the Drosophila wing through mechanical forces.

PLoS biology·2026

Same author

Regulation of Hippo signaling by Atrophin in the developing Drosophila wing.

Development (Cambridge, England)·2026

Same author

Mechanobiology of the Hippo-YAP Signaling Network.

Cold Spring Harbor perspectives in biology·2026

Same author

Jub-induced phosphorylation of Warts inhibits its activity and recruitment into biomolecular condensates.

Cell reports·2025

Same author

Dachsous-Fat Signaling Shapes the Drosophila Wing through Mechanical Forces.

bioRxiv : the preprint server for biology·2025

Same author

Contributions of the Dachsous intracellular domain to Dachsous-Fat signaling.

Development (Cambridge, England)·2024

Search research articles

Video Experimental Relacionado

Updated: May 9, 2026

Culturing and Manipulation of O9-1 Neural Crest Cells

Culturing and Manipulation of O9-1 Neural Crest Cells

Published on: October 9, 2018

La señalización del hipopótamo va a largo alcance.

Veronica A Codelia¹, Kenneth D Irvine

¹Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.

|August 21, 2012

Resumen

Los receptores acoplados a la proteína G regulan el tamaño de los órganos mediante el control de la vía Hippo-YAP, influyendo en el crecimiento celular y la muerte. Esta investigación vincula la estructura celular con la actividad de la vía y descubre nuevos reguladores extracelulares de YAP/TAZ.

Más Videos Relacionados

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

Published on: September 13, 2018

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

Videos de Experimentos Relacionados

Last Updated: May 9, 2026

Culturing and Manipulation of O9-1 Neural Crest Cells

Culturing and Manipulation of O9-1 Neural Crest Cells

Published on: October 9, 2018

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

Published on: September 13, 2018

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

Área de la Ciencia:

Biología celular Biología celular.
Biología Molecular Biología Molecular
Biología del desarrollo Biología del desarrollo.

Sus antecedentes:

La vía Hippo-YAP es un regulador crítico del tamaño del órgano, controlando la proliferación celular y la apoptosis.
Los homólogos de la levadura y el gusano de los componentes de la vía Hippo están involucrados en la forma y el crecimiento celular.

Objetivo del estudio:

Para investigar los reguladores aguas arriba de la vía Hippo-YAP.
Identificar nuevos factores extracelulares que modulan la actividad del coactivador transcripcional YAP/TAZ.

Principales métodos:

El estudio consistió en investigar la interacción entre los receptores acoplados a la proteína G y la vía Hippo-YAP.
Los enfoques experimentales probablemente incluyeron ensayos basados en células y técnicas de biología molecular para evaluar la actividad de YAP / TAZ.

Principales resultados:

Se identificaron receptores acoplados a la proteína G que actúan aguas arriba de YAP/TAZ.
La investigación refuerza el vínculo entre el citoesqueleto de actina y la señalización de la vía de Hippo.
Se descubrió una nueva clase de reguladores extracelulares secretados de YAP/TAZ.

Conclusiones:

Los receptores acoplados a la proteína G representan un nodo clave de señalización aguas arriba para la vía Hippo-YAP.
Este trabajo amplía nuestra comprensión de cómo las señales extracelulares regulan el tamaño de los órganos.
Los reguladores extracelulares identificados ofrecen objetivos terapéuticos potenciales para enfermedades que implican el crecimiento celular aberrante.