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Los singles activan la vía de interferencia del ARN
Cell
|September 4, 2012
Resumen
Los ARN monocatenados modificados químicamente pueden inducir efectivamente el silenciamiento de genes, igualando el rendimiento de los ARN de doble cadena. Este avance ofrece una nueva vía para las aplicaciones de interferencia de ARN.
Área de la Ciencia:
- Biología Molecular Biología Molecular
- Interferencia en el ARN Interferencia en el ARN
- Regulación genética Reglamento genético.
Sus antecedentes:
- Se sabe que los ARN de cadena única (ssRNA) interactúan con la vía de interferencia de ARN (RNAi).
- La vía del ARNi es un proceso biológico conservado que regula la expresión génica apuntando a los ARN mensajeros (ARNm).
- Por lo general, los ARN de doble cadena (dsRNA) son inductores más potentes del silenciamiento genético mediado por ARNi en comparación con los ARNs ss.
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This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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