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Videos de Conceptos Relacionados

Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer is an enzyme that can...
Duplication of Chromatin Structure02:05

Duplication of Chromatin Structure

The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...
Nucleosome Remodeling02:54

Nucleosome Remodeling

Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
The Nucleosome Core Particle01:12

The Nucleosome Core Particle

Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...

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Video Experimental Relacionado

Updated: May 19, 2026

Examination of Proteins Bound to Nascent DNA in Mammalian Cells Using BrdU-ChIP-Slot-Western Technique
09:14

Examination of Proteins Bound to Nascent DNA in Mammalian Cells Using BrdU-ChIP-Slot-Western Technique

Published on: January 14, 2016

La retención a través de la replicación del ADN: ¿modificación de la histona o modificador?

Susan M Abmayr, Jerry L Workman

    Cell
    |September 4, 2012
    PubMed
    Resumen
    Este resumen es generado por máquina.

    La metilación de la histona.

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    Área de la Ciencia:

    • Epigenética y biología molecular, centrándose en la regulación de la cromatina.

    Sus antecedentes:

    • La metilación de la histona es una marca epigenética clave.
    • Se cree que se mantiene a través de la replicación del ADN para asegurar la herencia epigenética.

    Objetivo del estudio:

    • Para investigar el mecanismo de mantenimiento de la metilación de histonas a través de la replicación del ADN.

    Principales métodos:

    • El estudio realizado por Petruk et al. examinó el comportamiento de los complejos de metiltransferasa durante la replicación.

    Principales resultados:

    • Los resultados sugieren que los complejos de metiltransferasa, no solo las marcas de histona, se asocian con la cromatina durante la replicación.
    • Estos complejos persistentes restablecen la metilación de histonas en el ADN recién sintetizado.

    Conclusiones:

    • La asociación cromatina de complejos de metiltransferasa es un mecanismo primario para mantener los patrones de metilación de histonas a través de la división celular.
    • Este hallazgo ofrece una nueva perspectiva sobre la herencia epigenética y la plantilla de cromatina.