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Células β diabéticas: ¿Ser o no ser?
1Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Cell
|September 18, 2012
Resumen
La diabetes tipo 2 puede surgir de la desdiferenciación de las células beta, no solo de la disfunción y la apoptosis. Esta vía alternativa ofrece nuevas dianas terapéuticas para la insuficiencia de insulina.
Área de la Ciencia:
- Endocrinología Endocrinología.
- Biología Molecular Biología Molecular
- Investigación de la diabetes Investigación de la diabetes.
Sus antecedentes:
- La patogénesis de la diabetes tipo 2 (DT2) está tradicionalmente relacionada con la disfunción de las células beta y la apoptosis.
- La insuficiencia de insulina es un sello distintivo de la diabetes tipo 2, que conduce a la hiperglucemia.
- Comprender los mecanismos alternativos de la insuficiencia de las células beta es crucial para las nuevas estrategias terapéuticas.
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