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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Especificar y mantener patrones de pigmentación en gatos domésticos y salvajes
Christopher B Kaelin1, Xiao Xu, Lewis Z Hong
1HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA.
Science (New York, N.Y.)
|September 22, 2012
Resumen
Los científicos descubrieron que el gen de la aminopeptidasa Q transmembrana (Taqpep) es clave para los patrones de pelaje felino, incluido el guepardo rey. Este gen, junto con Endothelin3 (Edn3), explica diversas marcas de gato a través de un proceso de desarrollo en dos etapas.
Área de la Ciencia:
- Genética La genética.
- Biología del desarrollo Biología del desarrollo.
- Zoología Zoología Zoología.
Sus antecedentes:
- Los patrones del pelaje felino exhiben variaciones diversas pero periódicas.
- Los patrones tabby de los gatos domésticos sugieren un mecanismo genético conservado influenciado por la selección.
Objetivo del estudio:
- Para identificar la base genética de la variación del patrón tabby en gatos domésticos.
- Investigar el papel de los genes identificados en la diversidad de patrones de pelaje en 31 especies de felinos.
- Para dilucidar los mecanismos moleculares subyacentes al desarrollo de patrones de pelaje felino.
Principales métodos:
- Identificación y secuenciación de genes en gatos domésticos.
- Análisis genómico comparativo de 31 especies de félidos.
- Estudios histológicos, de expresión genómica y de ratones transgénicos.
- Análisis de los patrones de expresión de Endothelin3 (Edn3).
Principales resultados:
- La aminopeptidasa Q transmembrana (Taqpep) fue identificada como el gen responsable de los patrones tabby en los gatos domésticos.
- Taqpep también fue identificado como la causa del fenotipo manchado y rayado único del guepardo rey.
- Se encontró que la expresión paracrina de Endothelin3 (Edn3) coordina las diferencias de color localizadas.
Conclusiones:
- Se propone un modelo de dos etapas para el desarrollo de patrones de pelaje felino.
- Taqpep establece un pre-patrón periódico durante el desarrollo de la piel.
- La expresión diferencial de Edn3 posteriormente implementa el patrón, explicando la diversa coloración felina.
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