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Disorders of the Male Reproductive System

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

Male Sexual Response: Erection & Ejaculation

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...

Penis

Penis

The penis serves a dual role in sexual reproduction and urination. It consists of three main regions: the glans penis, the body, and the root, each with distinct functions and unique anatomical features.
Anatomy of the Penis
The glans penis, or the head, is the terminal part of the penis and houses the external urethral orifice, the exit point for urine and semen. Covered by the prepuce, or foreskin, the glans is noted for its sensitivity and plays a key role in sexual pleasure. The body of the...

Infertility in Males

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

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Video Experimental Relacionado

Updated: May 18, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

La disfunción eréctil es la disfunción eréctil.

Rany Shamloul¹, Hussein Ghanem

¹Department of Urology, University of Ottawa, Ottawa, ON, Canada. ranyshamloul@gmail.com

Lancet (London, England)

|October 9, 2012

Resumen

La disfunción eréctil (DE) afecta a los hombres mayores de 40 años, vinculada al estilo de vida y a problemas cardiovasculares. Una nueva investigación explora las terapias génicas y celulares para una cura potencial más allá de los tratamientos actuales.

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Last Updated: May 18, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Área de la Ciencia:

Urología Urología Urología.
Cardiología Cardiología.
Salud de los hombres La salud de los hombres.

Sus antecedentes:

La disfunción eréctil (DE) es prevalente en hombres mayores de 40 años.
Asociado con la diabetes, la hipertensión, la obesidad y la inactividad.
Es un fuerte predictor de enfermedades cardiovasculares, lo que requiere una evaluación cardíaca.

Objetivo del estudio:

Revisar el vínculo entre la disfunción eréctil y las enfermedades cardiovasculares.
Para discutir los tratamientos actuales para la disfunción eréctil y sus limitaciones.
Explorar nuevas estrategias terapéuticas para la disfunción eréctil.

Principales métodos:

Revisión de la literatura sobre la fisiopatología de la disfunción eréctil y los factores de riesgo.
Análisis de la asociación entre la disfunción eréctil y la enfermedad cardiovascular.
Evaluación de los tratamientos actuales y emergentes para la disfunción eréctil.

Principales resultados:

La disfunción eréctil es un indicador significativo de la enfermedad de las arterias coronarias.
Los inhibidores de la fosfodiesterasa tipo 5 son terapias orales efectivas.
Las limitaciones de los tratamientos actuales impulsan la investigación en terapias avanzadas.

Conclusiones:

La gestión de la disfunción eréctil requiere la consideración de la salud cardiovascular.
Las terapias basadas en genes y células son prometedoras para futuras curas de la disfunción eréctil.
La investigación en curso tiene como objetivo superar las limitaciones de los tratamientos existentes para la disfunción eréctil.