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Updated: May 17, 2026

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
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Conocimiento estructural de las deshidrogenasas de NADH mitocondriales tipo II

Yue Feng1, Wenfei Li, Jian Li

  • 1State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Nature
|October 23, 2012
PubMed
Resumen

La levadura Ndi1, una deshidrogenasa de NADH tipo II (NDH-2), mantiene la homeostasis mitocondrial y muestra potencial terapéutico para enfermedades de deficiencia compleja I. Sus estructuras cristalinas revelan homodimerización y sitios de unión dual de ubiquinona cruciales para la catálisis.

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