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Hacia la terapia génica de la línea germinal de las enfermedades mitocondriales hereditarias

Masahito Tachibana1, Paula Amato, Michelle Sparman

  • 1Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, USA.

Nature
|October 30, 2012
PubMed
Resumen

El reemplazo de ADN mitocondrial (mtDNA) en ovocitos humanos a través de la transferencia de huso (ST) es factible. Esta técnica reemplazó con éxito el ADNmt, permitiendo el desarrollo embrionario normal y la derivación de células madre, ofreciendo esperanza para prevenir enfermedades mitocondriales hereditarias.

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