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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Efectos hidrofóbicos inversos aliviados por sustituciones de aminoácidos en la superficie de una proteína

A A Pakula1, R T Sauer

  • 1Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.

Nature
|March 22, 1990
PubMed
Resumen

Las sustituciones de aminoácidos en las superficies de las proteínas rara vez afectan la estabilidad. Sin embargo, las mutaciones en la proteína lambda Cro en la posición 26 aumentan significativamente la estabilidad, correlacionándose con una disminución de la hidrofobidad de la cadena lateral.

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