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Videos de Conceptos Relacionados

Regulation of Bacterial Virulence01:28

Regulation of Bacterial Virulence

Pathogenic bacteria employ a range of regulatory mechanisms to modulate the expression of virulence genes in response to environmental and host-derived signals. These mechanisms ensure that virulence factors are expressed only under favorable conditions, thereby optimizing infection and survival strategies.Mechanisms of Virulence RegulationKey regulatory strategies include:Two-Component Systems: These consist of a membrane-bound sensor kinase and a cytoplasmic response regulator. Environmental...
Other Stress Responses in Bacteria01:30

Other Stress Responses in Bacteria

Bacteria have global regulatory systems that control several types of stress mechanisms. These include Pho regulon and the heat shock response, which are essential systems for environmental adaptation, such as nutrient limitation and proteotoxic stress. The Pho regulon and the heat shock response exemplify bacterial resilience, enabling rapid adaptation to fluctuating environmental conditions.Pho RegulonBacteria require phosphorus for essential cellular processes, including nucleic acid...
Stringent Response in E. coli01:23

Stringent Response in E. coli

Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
Rab Cascades01:25

Rab Cascades

Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...

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Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

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Typhoid toxin: reframing enteric fever.

Microbiology and molecular biology reviews : MMBR·2026
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Interplay between SpaO variants shapes the architecture of the <i>Salmonella</i> type III secretion sorting platform.

mBio·2026
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p62 limits Salmonella Typhimurium in macrophages through its role in cell signalling.

Access microbiology·2026
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Oligomeric assembly of the gatekeeper InvE orchestrates hierarchical type III protein secretion in <i>Salmonella</i> Typhimurium.

Proceedings of the National Academy of Sciences of the United States of America·2026
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Interplay between SpaO variants shapes the architecture of the <i>Salmonella</i> type III secretion sorting platform.

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Video Experimental Relacionado

Updated: May 16, 2026

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages
11:10

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages

Published on: August 11, 2014

Una vía dependiente de Rab32 contribuye a la restricción del huésped de Salmonella typhi.

Stefania Spanò1, Jorge E Galán

  • 1Department of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.

Science (New York, N.Y.)
|November 20, 2012
PubMed
Resumen

Salmonella Typhi es una especie de Salmonella Typhi.

Área de la Ciencia:

  • Microbiología Microbiología.
  • Especificidad del huésped del patógeno.
  • La patogénesis bacteriana es la patogénesis bacteriana.

Sus antecedentes:

  • Salmonella Typhi es un patógeno humano con estricta especificidad de huésped.
  • Los mecanismos moleculares subyacentes a esta restricción del huésped no se comprenden bien.

Objetivo del estudio:

  • Para investigar la base molecular de la especificidad del huésped de Salmonella Typhi.
  • Para identificar los factores bacterianos que permiten la supervivencia en los huéspedes no permisivos.

Principales métodos:

  • Investigó el papel de una proteína efector del sistema de secreción de Salmonella Typhimurium tipo III.
  • Utilizó la interferencia de ARN para agotar los componentes de los factores huésped Rab32 y BLOC.
  • Examinó la supervivencia de Salmonella Typhi en macrófagos y tejidos de ratón.

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Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens
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Quantification of Cytosolic vs. Vacuolar Salmonella in Primary Macrophages by Differential Permeabilization
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Quantification of Cytosolic vs. Vacuolar Salmonella in Primary Macrophages by Differential Permeabilization

Published on: July 28, 2015

Videos de Experimentos Relacionados

Last Updated: May 16, 2026

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages
11:10

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages

Published on: August 11, 2014

Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens
07:40

Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens

Published on: October 25, 2019

Quantification of Cytosolic vs. Vacuolar Salmonella in Primary Macrophages by Differential Permeabilization
09:25

Quantification of Cytosolic vs. Vacuolar Salmonella in Primary Macrophages by Differential Permeabilization

Published on: July 28, 2015

Principales resultados:

  • Un único efector del sistema de secreción de tipo III de Salmonella Typhimurium permitió a Salmonella Typhi sobrevivir y replicarse en ratones.
  • Este efector se dirige a Rab32, una proteína involucrada en el tráfico de orgánulos relacionados con los lisosomas.
  • El agotamiento de los componentes Rab32 o BLOC permitió la supervivencia de Salmonella Typhi en los macrófagos de ratón.

Conclusiones:

  • Una proteína efector de Salmonella Typhimurium puede superar la especificidad del huésped de Salmonella Typhi.
  • Los complejos Rab32 y BLOC son factores huéspedes clave que restringen la infección por Salmonella Typhi.
  • Dirigirse a la maquinaria celular del huésped es un mecanismo para la adaptación del huésped bacteriano.