Video Experimental Relacionado
Updated: May 16, 2026
11:08
Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis
Published on: June 3, 2016
Inhibición no sináptica entre neuronas agrupadas en un circuito olfativo
Chih-Ying Su1, Karen Menuz, Johannes Reisert
1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.
Nature
|November 23, 2012
Resumen
Las neuronas receptoras olfativas compartimentadas (ORNs) de las moscas de la fruta se comunican directamente, con una activación transitoria de una neurona que inhibe a una neurona vecina. Esta inhibición lateral, probablemente a través del acoplamiento efáptico, influye en el comportamiento olfativo y puede codificar la saliencia.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Biología Sensorial Biología Sensorial
- Fisiología de los insectos.
Sus antecedentes:
- Los órganos sensoriales exhiben compartimentación, pero su significado funcional no está claro.
- Las neuronas receptoras olfativas (ORN) en Drosophila están compartimentadas.
- La comunicación directa entre las ROR no se ha demostrado previamente.
Objetivo del estudio:
- Investigar la comunicación directa entre las ROR compartimentadas.
- Para aclarar el mecanismo y el impacto funcional de las interacciones laterales entre las ROR.
- Explorar la prevalencia y las aplicaciones de la inhibición olfativa periférica.
Principales métodos:
- Registros electrofisiológicos de Drosophila ORNs.
- Análisis conductuales para evaluar las respuestas olfativas.
- Investigación de las ORN sensibles al Anopheles CO(2).
Principales resultados:
- Las ORN de Drosophila compartimentadas se comunican directamente a través de la inhibición lateral.
- La activación transitoria de una ORN inhibe la respuesta sostenida de una ORN vecina.
- Esta inhibición es independiente de la sinapsis, probablemente mediada por el acoplamiento epfático.
- La inhibición lateral periférica modula el comportamiento olfativo.
- Se observó una inhibición similar en las ORN sensibles al CO2 de Anopheles.
Conclusiones:
- La integración de la información olfativa ocurre a través de interacciones laterales entre las ROR.
- La inhibición lateral puede codificar la saliencia sensorial mediante el contraste de respuestas sostenidas y transitorias.
- La inhibición lateral periférica está muy extendida en los insectos, con aplicaciones potenciales en el control de plagas.
Videos de Conceptos Relacionados
01:25Olfaction
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
01:20Physiology of Smell and Olfactory Pathway
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
01:03Olfactory Receptors: Location and Structure
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
01:25Neural Circuits
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
01:09Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
01:12Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.