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Updated: May 16, 2026
07:08
Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency
Published on: February 2, 2024
La alquimia celular y la edad de oro de la reprogramación
1Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA. george.daley@childrens.harvard.edu
Cell
|December 11, 2012
Resumen
El Premio Nobel de Fisiología o Medicina 2012 honró los descubrimientos que permiten la reprogramación de las células. Los científicos demostraron que las células maduras se pueden revertir a un estado pluripotente, desafiando los conceptos biológicos establecidos.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- La reprogramación celular es la reprogramación celular.
- La investigación con células madre.
Sus antecedentes:
- El Premio Nobel de Fisiología o Medicina 2012 reconoció el trabajo innovador en la reprogramación celular.
- John Gurdon y Shinya Yamanaka independientemente hicieron descubrimientos fundamentales con respecto a la plasticidad celular.
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01:24Methods of Nuclear Reprogramming
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01:14Introduction to Nuclear Reprogramming
Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
01:28Forced Transdifferentiation
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...
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01:23Cellular Adaptation I: Introduction and Atrophy
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